Question:
Is anyone aware of any large prospective or retrosp. study on chronic
fatigue syndrome? It seems that it would be easy to carry out and I
am currently testing it on NHANES by comparing transferrin and LDL and
some of the immunology of the subjects.
anyone have recommendations for reliable biomarkers of CSF? There was
psychological questionnaire (fatigue) in nhanes. I am also looking at
comparing to physical activity and diet: i have added a glycemic index
score to the NHANES study.. cool huh.. it was easy as there are only
40 foods or so on the questionnaire..
I have seen it suggested in popular books that the more the population
is fed the more fatigued they seem to get. I'm sure that in the 1800s,
when a person was fatigued you would recommend bed rest and a nice big
meal. In 2002, people are overfed and will probably eat more when
they feel fatigued. Nightmarish.
immagine if we end up recommending very low calorie diets for the
fatigued!
Answer:
I don't know if this is going to help you any but I will list all of the
known causes of fatigue in humans (from a nutritional perspective). I did
buy the NHANES III cd database but I mix with statistics like oil mixes with
water. A student t-test is about as far as I can go without help from a
statistician.
Fatigue, and this includes chronic fatigue syndrome, is unlikely to have one
single cause. But multivariate analysis of the NHANES III data with the
question about fatigue may shed some light on this very common problem.
Here is my list of what is known to be associated with fatigue in humans:
Toxicity:
Cadmium
Lead
Mercury
Arsenic
Excessive Intake:
Vitamin A
Vitamin D
Vitamin E
Vitamin C
Riboflavin
Calcium
Magnesium
Iron
Copper
Potassium
Selenium
Deficient Intake:
Thiamin
Folic Acid
Pantothenic Acid
Iodine
Iron
Biotin
Chromium
Copper
Niacin
Phosphorus
Potassium
Sodium
Vitamin A
Vitamin B6
Vitamin C
Zinc
Manganese
Tin
Protein
Vitamin B12
Calories
Happy hunting (number crunching).
NHANESIII does have lead levels and if I remember correctly, past NHANES
data was analyzed and fatigue did have some correlation with the lead level
but I do not remember how strong that correlation was. NHANES III pointed
out that the average lead level decreased from NHANES II and this was seen
as being very positive in terms of mental alertness, hemoglobin profiles and
fatigue.
